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Causes of Hair Loss in Men

There are multiple causes that produce hair loss. A diet lacking in essential nutrients, thyroid problems, infections, stress, anemia, excessive cosmetics (dyes, flat iron), are factors which undoubtedly collaborate with alopecia.





The side effects of some treatments can also cause hair loss.


 Chemotherapy or radiation are one example.

However, Androgenic or Androgenetic Alopecia is the most common and affects-in some training to most men.
90% of men over 21 years has any recession in the frontotemporal area (inputs) and 50% of men over 40 have the crown area depopulated.



 
Androgenetic Alopecia

To be clear, 5 of 10 men (over 40 years) in both sectors suffer alopecia of the scalp and 9 of 10 (over 21 years) suffering from alopecia only in the area of the inputs


 important:
Remember it is absolutely normal to lose about a hundred hairs a day. Alopecia is diagnosed when new hairs are thinner than normal. We should not confuse a "fine hair" with alopecia as there are many people who have always had fine hair or looks weak. This does not necessarily mean alopecia.


 In androgenetic alopecia, responsible for hair loss are the enzyme 5-alpha-reductase and the hormone testosterone. The enzyme converts testosterone into dihydrotestosterone (DHT) who ultimately is responsible for reducing the follicles, making the membranes of the scalp from becoming rigid. Thus, the follicular structure receives less blood flow and new hair is weaker than normal and fine. At the end of the process, follicles wither and hair that falls out is not replaced by new hair.

 Have been studied DHT levels in people with androgenetic alopecia and usually normal. Therefore, scientists have found to be a high level of DHT alopecia resulting in only a particular sensitivity of the follicles against DHT.

Treatments that inhibit the enzyme 5-alpha-reductase have good results just because they prevent the production of DHT.


 Testosterone to dihydrotestosterone (DHT)

5-alpha-reductase

 Hair follicles receive testosterone (blue) and blood (red) blood vessels.
The enzyme 5-alpha-reductase (5aR) converts testosterone into DHT (yellow)



 DHT make affects the normal growth of hair

 In men genetically predisposed hair loss when DHT levels rise following happens:

1 - the time of the growth phase (anagen) is shortened.
2 - shrink follicles producing thinner hair.
3 - visible amount of hair is reduced.

Testosterone to dihydrotestosterone (DHT)

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